Fixed a URL reference

[egonw]

Pathway Information

WPID: WP4846__PR50
TITLE: SARS-CoV-2 and COVID-19 pathway
ORGANISM: Homo sapiens
DESCRIPTION: Collaborative project for curation biological processes involved in the COVID-19 disease after SARS-Cov-2 infection. It focuses on experimental evidence and plays with improved annotation of complexes and with the Evidence and Conclusion Ontology. The complexes link to EBI's Complex Portal, resulting from a collaboration with that database at the recent online ELIXIR biohackathon. Editing this pathway is (at this moment) coordinated via the wikipathways.slack.com #sarscov2 channel. Additionally, please feel free to add suggestions to the discussion page (see the tab at the top of this page). The large viral Spike protein (S or surface glycoprotein) forms trimers. It interacts with the host's ACE2 receptor to establish binding (Hoffmann et al 2020). There are suggestions for more than one cell entry mechanism, with the evidence for ACE2/TMPRSS2 entry being most clear now. Lack of expression of TMPRSS2 may explain age differences in COVID19 severity. In this mechanism, to enter the virus needs to be primed by the host protease TMPRSS2 that splits the Spike protein into 2 peptides S1 and S2. S1 contains the ACE2 receptor binding site, S2 binds to the host cell membrane which leads to membrane fusion, the start of the uptake process. The ACE2 receptor interaction was also suggested as the start of specific lung-damaging effects. Other human genes that may be involved in alternative cell uptake mechanisms include CTSL and SLC6A19.

Note: This is an edit to an existing pathway.

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Pathway Page Links

• Pending pathway page

• Current pathway page

Note: The above URLs will activate after ~5 min.

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Generate Metadata Files

• info.json generated
• datanodes.tsv generated
• refs.tsv generated
• No new author profiles needed
• bibliography.tsv generated
• .md generated

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Automated Testing

#	Test name	Notes	Result
1	Title Length	Title has at least 10 characters.	$${\color{green}PASS}$$
2	Description Length	Minor description change.	$${\color{green}PASS}$$
3	Data nodes	No nodes were deleted, modified, or added.	$${\color{green}PASS}$$

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Reviewer Checklist

• Interactions are connected
• Datanodes are annotated with database references
• A description, consisting of a 2-3 sentence overview of processes described in the pathway, is included
• At least one literature reference is provided
• At least one pathway ontology term is included
• Pathway title conforms to the guidelines
• Additional tests and checks are available in the review checklist spreadsheet.

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[github-actions]

This pull request has been rejected. Please review the comments and make necessary changes before resubmitting.