Update WP554.gpml

[AlexanderPico]

Pathway Information

WPID: WP554__PR11
TITLE: ACE inhibitor pathway
ORGANISM: Homo sapiens
DESCRIPTION: The core of this pathway was elucidated over a century ago and involves the conversion of angiotensinogen to angiotensin I (Ang I) by renin, its subsequent conversion to angiotensin II (Ang II) by angiotensin converting enzyme. Ang II activates the angiotensin II receptor type 1 to induce aldosterone synthesis, increasing water and salt resorption and potassium excretion in the kidney and increasing blood pressure. Source: PharmGKB (https://www.pharmgkb.org/pathway/PA2023) Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP554 CPTAC Assay Portal]

Note: This is an edit to an existing pathway.

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Pathway Page Links

• Pending pathway page

• Current pathway page

Note: The above URLs will activate after ~5 min.

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Generate Metadata Files

• info.json generated
• datanodes.tsv generated
• refs.tsv generated
• No new author profiles needed
• bibliography.tsv generated
• .md generated

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Automated Testing

#	Test name	Notes	Result
1	Title Length	Title has at least 10 characters.	$${\color{green}PASS}$$
2	Description Length	Description change exceeds 3 words or 10 characters.	$${\color{red}REVIEW REQUIRED}$$
3	Data nodes	Deleted nodes: 1\nModified nodes: 1\nAdded nodes: 1\n	$${\color{red}REVIEW REQUIRED}$$

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Reviewer Checklist

• Description review required
• Data nodes review required
• Interactions are connected
• Datanodes are annotated with database references
• A description, consisting of a 2-3 sentence overview of processes described in the pathway, is included
• At least one literature reference is provided
• At least one pathway ontology term is included
• Pathway title conforms to the guidelines
• Additional tests and checks are available in the review checklist spreadsheet.

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