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Hotspot residue consistently ignored during binder design with protein-anything protocol

Status: Open.

#215 In HannesStark/boltzgen;

· fatemesalehi19-ctrl opened on Apr 20, 2026

Translation shift / sign-flip for second half of batch (indices 25-49) on large targets (1TUB)

Status: Open.

#214 In HannesStark/boltzgen;

· geraseva opened on Apr 16, 2026

Is it possible to do pure motif scaffolding, not binder design?

Status: Open.

#213 In HannesStark/boltzgen;

· batch2k opened on Apr 15, 2026

Nanobody and an unusual glucose molecule

Status: Open.

#211 In HannesStark/boltzgen;

· xushaojie-cola opened on Apr 14, 2026

Clashing superposition of binder and target in intermediate designs for binder re-design

Status: Open.

#209 In HannesStark/boltzgen;

· alexandre239 opened on Apr 3, 2026

Question - memory usage guidelines?

Status: Open.

#208 In HannesStark/boltzgen;

· dennisbrookner opened on Mar 24, 2026

How difficult it is to design binder for RNA molecules

Status: Open.

#207 In HannesStark/boltzgen;

· nanolife1 opened on Mar 20, 2026

📋 Documentation Enhancement Suggestion

Status: Open.

#205 In HannesStark/boltzgen;

· croviatrust opened on Mar 19, 2026

Unclosed file handles in writer.py — ResourceWarning spam

Status: Open.

#204 In HannesStark/boltzgen;

· goran-mh opened on Mar 18, 2026

Missing pLDDT from BoltzGen metrics

Status: Open.

#202 In HannesStark/boltzgen;

· alexandre239 opened on Mar 17, 2026

N-terminal binding site - too close to terminus or just need more designs?

Status: Open.

#201 In HannesStark/boltzgen;

· fatemesalehi19-ctrl opened on Mar 17, 2026

Comparison to immunisation sequences

Status: Open.

#200 In HannesStark/boltzgen;

· peterkilfeather opened on Mar 16, 2026