Search results

Thyroid tumor POLE signature analysis

mechanisticResolves the mechanistic paradoxResolves the mechanistic paradox

tier-2Medium-term priority (3-12 months)Medium-term priority (3-12 months)

Status: Open.

#8 In Bloomed-Health/POLE-Frameshift;

· bloo-berries opened on Apr 15, 2026

AMA-specific ELISA + extended autoimmune panel

blood-basedAchievable from peripheral blood drawAchievable from peripheral blood draw

tier-1Immediate priority (0-3 months)Immediate priority (0-3 months)

Status: Open.

#7 In Bloomed-Health/POLE-Frameshift;

· bloo-berries opened on Apr 15, 2026

MMR IHC, MSI testing, MLH1 methylation analysis

mechanisticResolves the mechanistic paradoxResolves the mechanistic paradox

tier-1Immediate priority (0-3 months)Immediate priority (0-3 months)

Status: Open.

#6 In Bloomed-Health/POLE-Frameshift;

· bloo-berries opened on Apr 15, 2026

Immunophenotyping + TCR repertoire sequencing

blood-basedAchievable from peripheral blood drawAchievable from peripheral blood draw

therapeuticDirectly informs treatment decisionsDirectly informs treatment decisions

tier-1Immediate priority (0-3 months)Immediate priority (0-3 months)

Status: Open.

#5 In Bloomed-Health/POLE-Frameshift;

· bloo-berries opened on Apr 15, 2026

CHIP profiling + duplex sequencing / NanoSeq on PBMCs

blood-basedAchievable from peripheral blood drawAchievable from peripheral blood draw

mechanisticResolves the mechanistic paradoxResolves the mechanistic paradox

tier-1Immediate priority (0-3 months)Immediate priority (0-3 months)

Status: Open.

#4 In Bloomed-Health/POLE-Frameshift;

· bloo-berries opened on Apr 15, 2026

Allele-specific expression / NMD escape test

blood-basedAchievable from peripheral blood drawAchievable from peripheral blood draw

mechanisticResolves the mechanistic paradoxResolves the mechanistic paradox

tier-1Immediate priority (0-3 months)Immediate priority (0-3 months)

Status: Open.

#3 In Bloomed-Health/POLE-Frameshift;

· bloo-berries opened on Apr 15, 2026

Mutational signature decomposition (SBS10a/b/28 vs. alternatives)

mechanisticResolves the mechanistic paradoxResolves the mechanistic paradox

tier-1Immediate priority (0-3 months)Immediate priority (0-3 months)

Status: Open.

#2 In Bloomed-Health/POLE-Frameshift;

· bloo-berries opened on Apr 15, 2026

Paired tumor-normal WGS with LOH analysis at POLE locus

mechanisticResolves the mechanistic paradoxResolves the mechanistic paradox

tier-1Immediate priority (0-3 months)Immediate priority (0-3 months)

Status: Open.

#1 In Bloomed-Health/POLE-Frameshift;

· bloo-berries opened on Apr 15, 2026