diff --git a/CHANGES.md b/CHANGES.md
index 3728cd8d..819f7d4e 100644
--- a/CHANGES.md
+++ b/CHANGES.md
@@ -6,6 +6,7 @@
 
 - remove pgstac 0.8.6 in tests and update documentation ([#354](https://github.com/stac-utils/stac-fastapi-pgstac/pull/354))
 - simplify `extensions.query.Operator` class, by removing unused `operator` method and unncessary dependencies ([#364](https://github.com/stac-utils/stac-fastapi-pgstac/pull/364))
+- handle `ENABLE_TRANSACTIONS_EXTENSIONS`, `ENABLED_EXTENSIONS` and `UVICORN_ROOT_PATH` environment configuration variables via the `config.Settings` class ([#368](https://github.com/stac-utils/stac-fastapi-pgstac/pull/368))
 
 ### Added
 
diff --git a/stac_fastapi/pgstac/app.py b/stac_fastapi/pgstac/app.py
index 844bd49f..abe4f1e4 100644
--- a/stac_fastapi/pgstac/app.py
+++ b/stac_fastapi/pgstac/app.py
@@ -5,7 +5,6 @@
 If the variable is not set, enables all extensions.
 """
 
-import os
 from contextlib import asynccontextmanager
 from typing import cast
 
@@ -93,16 +92,12 @@
     "collection_search",
 }
 
-if ext := os.environ.get("ENABLED_EXTENSIONS"):
+if ext := settings.enabled_extensions:
     enabled_extensions = set(ext.split(","))
 
 application_extensions: list[ApiExtension] = []
 
-with_transactions = os.environ.get("ENABLE_TRANSACTIONS_EXTENSIONS", "").lower() in [
-    "yes",
-    "true",
-    "1",
-]
+with_transactions = settings.enable_transactions_extensions
 if with_transactions:
     application_extensions.append(
         TransactionExtension(
@@ -216,7 +211,7 @@ def run():
             port=settings.app_port,
             log_level="info",
             reload=settings.reload,
-            root_path=os.getenv("UVICORN_ROOT_PATH", ""),
+            root_path=settings.uvicorn_root_path,
         )
     except ImportError as e:
         raise RuntimeError("Uvicorn must be installed in order to use command") from e
diff --git a/stac_fastapi/pgstac/config.py b/stac_fastapi/pgstac/config.py
index 3a610a3f..2d7db5a6 100644
--- a/stac_fastapi/pgstac/config.py
+++ b/stac_fastapi/pgstac/config.py
@@ -199,6 +199,8 @@ class Settings(ApiSettings):
     invalid_id_chars: list[str] = DEFAULT_INVALID_ID_CHARS
     base_item_cache: type[BaseItemCache] = DefaultBaseItemCache
 
+    enabled_extensions: str = ""
+    enable_transactions_extensions: bool = False
     validate_extensions: bool = False
     """
     Validate `stac_extensions` schemas against submitted data when creating or updated STAC objects.
@@ -220,6 +222,8 @@ class Settings(ApiSettings):
         "Content-Type",
     )
 
+    uvicorn_root_path: str = ""
+
     testing: bool = False
 
     @model_validator(mode="after")
diff --git a/tests/test_config.py b/tests/test_config.py
index 195b776e..baab44d9 100644
--- a/tests/test_config.py
+++ b/tests/test_config.py
@@ -77,6 +77,21 @@ async def test_pg_settings_attributes(monkeypatch):
             )
 
 
+@pytest.mark.parametrize(
+    "env_var, expected",
+    [
+        ("TRUE", True),
+        ("YES", True),
+        ("1", True),
+    ],
+)
+def test_settings_enable_transactions_extensions(monkeypatch, env_var, expected):
+    """Test that enable_transactions_extensions is properly parsed from environment variable."""
+    monkeypatch.setenv("ENABLE_TRANSACTIONS_EXTENSIONS", env_var)
+    settings = Settings()
+    assert settings.enable_transactions_extensions == expected
+
+
 @pytest.mark.parametrize(
     "cors_origins",
     [