diff --git a/cmake/onnxruntime_mlas.cmake b/cmake/onnxruntime_mlas.cmake
index c0ab948b41fff..69d5f85bbd903 100644
--- a/cmake/onnxruntime_mlas.cmake
+++ b/cmake/onnxruntime_mlas.cmake
@@ -561,9 +561,13 @@ else()
           if(COMPILES_P10)
             check_cxx_source_compiles("
               #ifdef _AIX
+              #include <sys/systemcfg.h>
+              #if !defined(POWER_10)
               #define POWER_10       0x40000
+              #endif
+              #if !defined(POWER_10_ANDUP)
               #define POWER_10_ANDUP (POWER_10)
-              #include <sys/systemcfg.h>
+              #endif
               #define __power_10_andup() (_system_configuration.implementation & POWER_10_ANDUP)
               int main() {
                 bool HasP10 = (__power_10_andup() && __power_mma_version() == MMA_V31);
diff --git a/onnxruntime/core/mlas/lib/platform.cpp b/onnxruntime/core/mlas/lib/platform.cpp
index 528e71bcffed1..278ea29b6f27f 100644
--- a/onnxruntime/core/mlas/lib/platform.cpp
+++ b/onnxruntime/core/mlas/lib/platform.cpp
@@ -30,9 +30,11 @@ Module Name:
 #if defined(__linux__)
 #include <sys/auxv.h>
 #elif defined(_AIX)
+#include <sys/systemcfg.h>
+#if !defined(POWER_10)
 #define POWER_10       0x40000
 #define POWER_10_ANDUP (POWER_10)
-#include <sys/systemcfg.h>
+#endif
 #define __power_10_andup() (_system_configuration.implementation & POWER_10_ANDUP)
 #endif
 #endif