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README.md

Information Integration

Information-theoretic analysis applied to biological data integration and network analysis, measuring entropy across DNA, RNA, single-cell, multi-omics, and ML pipeline outputs.

Contents

File Purpose
integration.py Domain-specific entropy analysis for DNA, RNA, single-cell, multi-omics, ML
networks.py Network entropy, information flow, community detection, centrality measures

Key Functions

Function Description
dna_integration() Compute entropy and information content of DNA sequence data
rna_integration() Entropy analysis of RNA expression matrices
singlecell_integration() Information metrics for single-cell expression profiles
multiomics_integration() Cross-omics mutual information and integration scores
ml_integration() Information-theoretic evaluation of ML feature sets
network_entropy() Shannon or von Neumann entropy of a network graph
information_flow() Random-walk or diffusion-based information flow between nodes
information_community_detection() Community detection via infomap or map equation
network_information_centrality() Entropy-based node centrality ranking
network_motif_information() Information content of network motif patterns
information_graph_distance() Entropy-based distance between two graphs

Usage

from metainformant.information.integration.integration import dna_integration
from metainformant.information.integration.networks import network_entropy

results = dna_integration(sequences, method="entropy")
h = network_entropy(graph, method="shannon")