diff --git a/devito/passes/clusters/derivatives.py b/devito/passes/clusters/derivatives.py
index 5af92a3208..d244704058 100644
--- a/devito/passes/clusters/derivatives.py
+++ b/devito/passes/clusters/derivatives.py
@@ -241,7 +241,8 @@ def callback(self, clusters, prefix, subs0=None, seen=None):
                 else:
                     exprs.append(uxreplace(e, {**subs0, **subs}))
 
-            processed.append(c.rebuild(exprs=exprs))
+            if exprs:
+                processed.append(c.rebuild(exprs=exprs))
 
         seen.update(processed)