Cause:
If the configured backup-target happens to be unavailable, the "Apply"-Button stays disabled, so that the cannot be disabled.
Effect:
If backup runs without something mounted at the configured backup-target's path, the appdata-backup will fill up the system memory, which implies lots of further problems.
Workaround:
Overwrite the configured backup-target's path with something, that is available, so that the "Apply"-Button becomes enabled, so that schedule can be disabled.