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Some background in this thesis "Mathematical Modeling to Connect Bone Responses to Systemic Mechanisms"
https://www.proquest.com/docview/3068633067?pq-origsite=gscholar&fromopenview=true&sourcetype=Dissertations+&+Theses=
The paper is: https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/aic.17809
SBML model and code here: https://github.com/ashleefv/Wnt10bBoneCompartment